Vasopressin Receptor Antagonists. Therapeutic Efficacy of Vasopressin Receptor Antagonists.
نویسندگان
چکیده
منابع مشابه
Vasopressin and Vasopressin Receptor Antagonists
Vasopressin, a neurohypophyseal peptide hormone, is the endogenous agonist at V1a, V1b, and V2 receptors. The most important physiological function of vasopressin is the maintenance of water homeostasis through interaction with V2 receptors in the kidney. Vasopressin binds to V2 receptor and increases the number of aquaporin-2 at the apical plasma membrane of collecting duct principal cells. Th...
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Arginine vasopressin (AVP) is a 9-amino acid peptide that is secreted from the posterior pituitary in response to high plasma osmolality and hypotension. AVP has important roles in circulatory and water homoeostasis, which are mediated by oxytocin receptors and by AVP receptor subtypes: V(1a) (mainly vascular), V(1b) (pituitary), and V(2) (renal). Vaptans are orally and intravenously active non...
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Vasopressin receptor antagonists are a new class of drugs that address the problems of fluid retention, hyponatremia, and renal dysfunction in heart failure. Elevated vasopressin levels in heart failure cause myocardial fibrosis, hypertrophy and vasoconstriction by activating the V1a receptors, as well as water retention and hyponatremia by activating V2 receptors. Antagonism of V1a receptors a...
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eart failure (HF) is among the most common causes of ospitalization, and its incidence will likely increase in an ging population of “survivors” (1). Pharmacological treatent targeted at neurohormonal activation has improved urvival, but mortality remains substantial in patients with F, thus warranting the search for novel therapeutic aproaches. Novel agents under investigation for the treatent...
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ژورنال
عنوان ژورنال: Internal Medicine
سال: 1998
ISSN: 0918-2918,1349-7235
DOI: 10.2169/internalmedicine.37.217